Cardiac biomarkers are proteins that are released into the blood as a result of cardiac muscle injury. Their measurement provides an indication of the extent of damage. Markers such as cardiac troponin-I are specific for cardiac injury whereas others (myoglobin, FABP, and MLC-1) are also elevated as a result of skeletal muscle damage. In humans, myoglobin and FABP are the first biomarkers to rise above baseline, increasing measurably 2-4 hours after cardiac damage, peaking at 9-12 hours, and returning to baseline within 24-36 hours. Cardiac troponin-I rises above normal levels within 4-6 hours, peaks at 12-24 hours, and remains elevated for 6-10 days. Our general experience with animal cardiac biomarkers is that their levels peak rapidly after injury (1-2 hours) and that they return to baseline within 1-2 days.
We manufacture cardiac biomarker ELISA kits, SPARCL™ kits and purified cardiac biomarkers for cardiovascular research in species including mouse, rat, rabbit, dog, pig, and monkey. Our continuing goal is to offer quality products that can be used to speed development of new cardiovascular drugs and treatment strategies.